2-Bromoethyl methyl ether → HCID 66860376, compound

HRID 255058Notes

Reaction equation

HRID 255058 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[CH2:5][C:6]1[S:10][C:9]([NH2:11])=[N:8][CH:7]=1.[CH3:15][O:16][CH2:17][CH2:18]Br>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[CH2:5][C:6]1[S:10][C:9](=[NH:11])[N:8]([CH2:18][CH2:17][O:16][CH3:15])[CH:7]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 33871345-(3-fluorobenzyl)-1,3-thiazol-2-amine

Product 1

HCID 66860376HCID 66860376, compound

Procedure

A mixture of 5-(3-fluoro-benzyl)-thiazol-2-ylamine (330 mg, 1.59 mmol) and 2-bromoethyl methyl ether (0.50 mL, 5.34 mmol) was processed according to the method of Example 43A to afford the title compound: MS (LC/MS) m/z 267 (M+H)+.

Sources & evidence

ORD record
ord-6ba7533479cd4559b77f38d8027f61c0
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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