化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Adamantane-1-carboxylic acid (5,6-dihydro-4H-cyclopentathiazol-2-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Adamantanecarbonyl chloride | HCID 98915 | — |
| 反応物 | 5,6-Dihydro-4H-cyclopenta[d]thiazol-2-amine hydrochloride | HCID 16253246 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Adamantane-1-carboxylic acid (5,6-dihydro-4H-cyclopentathiazol-2-yl)-amide | HCID 75413254 | — |
反応手順
A mixture of 5,6-dihydro-4H-cyclopentathiazole-2-ylamine hydrochloride (400 mg, 2.27 mmol), 1-adamantanecarbonyl chloride (540 mg, 2.72 mmol), 4-dimethylaminopyridine (100 mg, 0.82 mmol) and triethylamine (632 μL, 4.54 mmol) in 30 mL of THF was processed according to the method of Example 1A to afford the title compound: MS (DCI/NH3) m/z 303 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07875639B2 |
| 出典データセット | uspto-grants-2011_01 |
| ORD ID | ord-0c9a98e88bee45bcbc0cfc0f681e47bb |
| 出典メモ | uspto-grants-2011_01 |