Triethylamine → HCID 66858783, compound

HRID 255111Notes

Reaction equation

HRID 255111 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH2:10].Cl.Cl[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.C(N(CC)CC)C>>[N:15]1([CH2:14][CH2:13][N:3]2[C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[S:1][C:2]2=[NH:10])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 8706Benzo(d)thiazol-2-amineHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

Product 1

HCID 66858783HCID 66858783, compoundYield 26%

Procedure

Benzothiazol-2-ylamine (1.0 g, 6.6 mmol), 4-(2-chloroethyl)-morpholine hydrochloride (1.2 g, 6.6 mmol) and triethylamine (2.8 mL, 20 mmol) were heated at 80° C. for 16 hours. The solid was recrystallized from ethyl acetate, collected by filtration, dried under vacuum to provide 0.45 g (26%) of the title compound. MS (DCI/N3) m/z 264 (M+H)+.

Workup

  1. customThe solid was recrystallized from ethyl acetate
  2. filtrationcollected by filtration
  3. customdried under vacuum

Sources & evidence

ORD record
ord-993b8949da774c63b7da2e402ba3dde4
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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