HuagongsheHuagongshe Chemistry Print Report · For research reference only
Furan, 2-(bromomethyl)tetrahydro- → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Furan, 2-(bromomethyl)tetrahydro- | HCID 14501 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 5-methyl-3-((tetrahydrofuran-2-yl)methyl)thiazol-2(3H)-imine | HCID 66851698 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (1.0 g, 8.7 mmol) and 2-(bromomethyl)tetrahydrofuran (1.1 mL, 10 mmol) was warned to 85° C. and stirred for 24 hours. The mixture was cooled to ambient temperature and purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07875639B2 |
| Source dataset | uspto-grants-2011_01 |
| ORD ID | ord-ab6fcf5ac6ee429e8e627b98d47d73e4 |
| Source note | uspto-grants-2011_01 |