反应详情

A mixture of 2-amino-5-methylthiazole (1.0 g, 8.7 mmol) and 2-(bromomethyl)tetrahydrofuran (1.1 mL, 10 mmol) was warned to 85° C. and stirred for 24 hours. The mixture was cooled to ambient temperature and purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.

1. customwas warned to 85° C.
2. custompurified via column chromatography (SiO2, 10% methanol in ethyl acetate