2-Bromoethyl methyl ether → 3-(2-methoxyethyl)-5-(tetrahydro-2H-pyran-4-yl)thiazol-2(3H)-imine hydrobromide

HRID 255126Notes

Reaction equation

HRID 255126 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[S:11][C:10]([NH2:12])=[N:9][CH:8]=2)[CH2:3][CH2:2]1.[CH3:13][O:14][CH2:15][CH2:16][Br:17]>>[BrH:17].[CH3:13][O:14][CH2:15][CH2:16][N:9]1[CH:8]=[C:7]([CH:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[S:11][C:10]1=[NH:12]

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 866190505-(Oxan-4-yl)-1,3-thiazol-2-amine

Product 1

HCID 668589493-(2-methoxyethyl)-5-(tetrahydro-2H-pyran-4-yl)thiazol-2(3H)-imine hydrobromide

Procedure

A mixture of Example 138A and commercially available 2-bromoethyl methyl ether (Aldrich) was processed using the method described in Example 46A to afford the title compound. MS (ESI+) m/z 24.3 (M+H)+.

Sources & evidence

ORD record
ord-d5010461d6a9474382cfdc7435dd57b6
Source dataset
uspto-grants-2011_01
Patent number
US07875639B2

Reaction notes

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