反应详情

7-Bromo-2-chloroquinoline was heated in 5M HCl (100 mL) and dioxane (10 mL) for 1 hour at reflux. The Reaction mixture was cooled, filtered and washed with water to give the title compound, 2.89 g, as a colorless solid, mp 295° C.

1. temperatureThe Reaction mixture was cooled
2. filtrationfiltered
3. washwashed with water