反应详情

The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.286 g, 1.0 mmol) was mixed with 4-carboxyphenyl isothiocyanate (0.185 g, 1.03 mmol) in tetrahydrofuran (40 mL). The solvent was boiled off on the rotary evaporator (no vacuum), and ethyl acetate was added to the residue and the insoluble material was collected by filtration. The collected solid was taken up in tetrahydrofuran, concentrated to dryness, and triturated again with ethyl acetate to give the product as a white solid (0.180 g), mp 201-203° C.

1. customThe solvent was boiled off on the rotary evaporator (no vacuum), and ethyl acetate
2. additionwas added to the residue
3. filtrationthe insoluble material was collected by filtration
4. concentrationconcentrated to dryness
5. customtriturated again with ethyl acetate