反应详情

温度

50 °C

The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine (0.277 g, 1.0 mmol) was mixed with 3-isothiocyanatopyridine (0.146 g, 1.07 mmol) in tetrahydrofuran (10 mL) and was heated briefly to 50° C. and then allowed to stand overnight at room temperature. The tetrahydrofuran was removed on the rotary evaporator to give a solid. The solid was triturated with hexanes/ethyl acetate, 1/1, v/v and was triturated a second time with hexanes/ethyl acetate, 4/1, v/v to give the product (0.309 g), mp 128-130° C.

1. customThe tetrahydrofuran was removed on the rotary evaporator
2. customto give a solid
3. customThe solid was triturated with hexanes/ethyl acetate, 1/1, v/v
4. customwas triturated a second time with hexanes/ethyl acetate, 4/1, v/v