huagongshe.com
HRID255235

反应详情

EQUATION

反应方程式

HRID 255235 的结构方程式

REACTANTS

反应物

3
结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：O=Cc1ccc2c(n1)NC(=O)CO2
HCID21873737

未命名化合物

结构：N#Cc1ccc2c(c1)N(CC[C@H]1CC[C@H](N)CC1)C(=O)CO2
HCID178509460

未命名化合物

2 次

PRODUCTS

生成物

1
结构：N#Cc1ccc2c(c1)N(CC[C@H]1CC[C@H](NCc3ccc4c(n3)NC(=O)CO4)CC1)C(=O)CO2
HCID178509461

未命名化合物

收率 7%

PROCEDURE

实验过程

4-[2-(Trans-4-aminocyclohexyl)ethyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carbonitrile (Intermediate 77), 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde (WO 2004/058144) (1.73 mmol) and sodium cyanoborohydride were reacted following the procedure described for Example 21 to give the product in 7% yield, as an off-white solid.

WORKUP

后处理

  1. customto give the product in 7% yield