1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → HCID 66775065, compound

HRID 255258Notes

Reaction equation

HRID 255258 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16]C(=O)OC(C)(C)C)[CH2:12][CH2:11]2)[C:6]2[CH:24]=[CH:25][CH:26]=[CH:27][C:5]=2[O:4][CH2:3]1.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:16][CH:13]1[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][N:7]2[C:6]3[CH:24]=[CH:25][CH:26]=[CH:27][C:5]=3[O:4][CH2:3][C:2]2=[O:1])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642628HCID 86642628, compound2×

Product 1

HCID 66775065HCID 66775065, compound

Procedure

tert-Butyl {1-[2-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 98) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was obtained as a colorless solid and used without further purification for the next step (quantitative yield).

Sources & evidence

ORD record
ord-eecdf36444d04f5abd054c147683dc4f
Source dataset
uspto-grants-2011_01
Patent number
US07875715B2

Reaction notes

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