反应详情

温度

110 °C

A suspension of 3-chloro-6-methoxy-2-methylquinoxaline (Intermediate 162, 1.5 g, 7.21 mmol) in 5M HCl (30 mL) was heated to 110° C. for 1 hour. The reaction mixture was neutralized with saturated sodium carbonate solution, diluted with water and extracted with ethyl acetate (3 times). The combined organic phases were dried over magnesium sulfate and concentrated to a small volume under reduced pressure. The precipitate was collected by filtration to give 1.0 g (71%) of product as an off-white solid.

1. extractionextracted with ethyl acetate (3 times)
2. dry with materialThe combined organic phases were dried over magnesium sulfate
3. concentrationconcentrated to a small volume under reduced pressure
4. filtrationThe precipitate was collected by filtration