反应详情

A mixture of 8.0 g (0.026 mol) of product of Example 2, 3.6 g (0.026 mol) or potassium carbonate, 20 g of methyl iodide, and 50 ml of acetone was held at reflux for 6 hours and concentrated. The residue was treated with water and extracted with ether. The ether extract was washed once with 30 ml of 10% NaOH, dried, and concentrated. The residue was crystallized from hexane to give 6.91 g (82.5%) of product; mp 58.5°-59.5° C.

1. temperatureat reflux for 6 hours
2. concentrationconcentrated
3. additionThe residue was treated with water
4. extractionextracted with ether
5. extractionThe ether extract
6. washwas washed once with 30 ml of 10% NaOH
7. customdried
8. concentrationconcentrated
9. customThe residue was crystallized from hexane