Isopropylamine → HCID 14013800, compound

HRID 255417Notes

Reaction equation

HRID 255417 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7](Cl)[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[CH:25]([NH2:28])([CH3:27])[CH3:26]>CN(C=O)C>[CH:25]([NH:28][C:7]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:20])([F:21])[F:22])[N:4]=[C:3]([C:2]([F:24])([F:23])[F:1])[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10])([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 14013761HCID 14013761, compound

Product 1

HCID 14013800HCID 14013800, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared as described in Example 37: 7.0 g (0.018 mol) of product of Example 27, 3.2 ml (0.037 mol) of isopropylamine in 30 ml of DMF were reacted at room temperature for 1/2 hour affording a brown oil which was kugelrohr distilled at 78 Pa, pot temperature 95° C., to give 6.07 g (83.8%) of product as a yellow oil, nD25 1.4560.

Workup

  1. customThis compound was prepared
  2. customaffording a brown oil which
  3. distillationwas kugelrohr distilled at 78 Pa, pot temperature 95° C.

Sources & evidence

ORD record
ord-d8148bb3d6544f4c919e84be2520d1a7
Source dataset
uspto-grants-1987_10
Patent number
US04698093

Reaction notes

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