Dimethylformamide → HCID 14013801, compound

HRID 255418Notes

Reaction equation

[F:1][C:2]([F:24])([F:23])[C:3]1[C:8]([C:9]([O:11][CH2:12]C)=[O:10])=[C:7](Cl)[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[CH2:25]([NH:28][CH2:29][CH2:30][CH3:31])[CH2:26][CH3:27].[CH3:32]N(C=O)C>>[CH2:25]([N:28]([CH2:29][CH2:30][CH3:31])[C:7]1[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:20])([F:22])[F:21])[N:4]=[C:3]([C:2]([F:24])([F:23])[F:1])[C:8]=1[C:9]([O:11][CH2:12][CH3:32])=[O:10])[CH2:26][CH3:27]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 8902Dipropylamine

HCID 14013761HCID 14013761, compound

Product 1

HCID 14013801HCID 14013801, compoundYield 96.3%

Procedure

This compound was prepared as described in Example 37: 7.0 g (0.018 mol) of product of Example 27, 5.1 ml (0.037 mol) of dipropylamine in 30 ml of DMF were reacted at room temperature affording 7.7 g (96.3%) of solid which was recrystallized in hot hexane to give 2.19 g of product as a tan solid; mp 65°-66° C.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-1cab4cc23e46468e906cfaec2d8991ff
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04698093

Reaction notes

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