Trifluoroacetic acid → HCID 14013838, compound

HRID 255437Notes

Reaction equation

HRID 255437 reaction equation
[CH:1]1([NH:4][C:5]2[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([CH:15](F)F)[N:8]=[C:7]([C:18]([F:21])([F:20])[F:19])[C:6]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl.[Zn]>[CH:1]1([NH:4][C:5]2[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([CH3:15])[N:8]=[C:7]([C:18]([F:20])([F:21])[F:19])[C:6]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14013807HCID 14013807, compound

Product 1

HCID 14013838HCID 14013838, compoundYield 59%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 6344DichloromethaneSolvent

Procedure

This compound was prepared as described in Example 85: 17 g (0.264 mol) of zinc dust, 4.76 g (0.012 mol) of product of Example 56 and 17 ml of trifluoroacetic acid in 100 ml of CH2Cl2 were reacted affording 2.44 g (59%) of product after kugelrohr distillation at 100°-140° C./53 Pa as a light yellow oil, nD25 1.5032.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c322674036df47f09c3779c73cd52c1e
Source dataset
uspto-grants-1987_10
Patent number
US04698093

Reaction notes

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