反应详情

Ethyl 6-hydroxy-1H-indole-2-carboxylate (4.6 g, 0.02 M) was heated under reflux with allylbromide (3 g, 2.2 ml, 0.025 M), K2CO3 (4.14 g 0.03 M) and acetone (150 ml) for 20 hours. On cooling the mixture was poured into brine and extracted into ethyl acetate, washed with brine, dried over magnesium sulphate and evaporated to dryness. The resulting crude brown solid was purified by extraction into hot 60°-80° petroleum ether to yield a yellow solid which was dried in vacuo, 4 g, 72%, mp 89°-91°.

1. temperatureOn cooling the mixture
2. extractionextracted into ethyl acetate
3. washwashed with brine
4. dry with materialdried over magnesium sulphate
5. customevaporated to dryness
6. customThe resulting crude brown solid was purified by extraction into hot 60°-80° petroleum ether
7. customto yield a yellow solid which
8. customwas dried in vacuo, 4 g, 72%, mp 89°-91°