Acetic Anhydride → HCID 178492024, compound

HRID 255529Notes

Reaction equation

HRID 255529 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:21]3[C:20]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[N+:14]([O-])=[CH:13][C:12]=3[N:11]=[CH:10]2)=[CH:5][CH:4]=1.C(OC(=O)C)(=[O:25])C>>[OH:25][C:13]1[C:12]2[N:11]=[CH:10][N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:21]=2[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N:14]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 13958384HCID 13958384, compound

Product 1

HCID 178492024HCID 178492024, compound

Procedure

Using the method of Example 133, 1-(4-methoxyphenyl)-1H-imidazo[4,5-c]quinolin-5-oxide (from Exmaple 86) was reacted with acetic anhydride to provide 4-hydroxy-1-(4-methoxyphenyl)-1H-imidazo[4,5-c]quinoline m.p. >300° C. after recrystallization from N,N-dimethylformamide. Analysis: Calculated for C17H13N3O2 : %C, 70.1; %H, 4.5; %N, 14.4; Found: %C, 70.0; %H, 4.4; %N, 14.5.

Sources & evidence

ORD record
ord-26c94eb22849487589ff545c25795bd5
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

Loading…