Formic Acid → HCID 13958443, compound

HRID 255533Notes

Reaction equation

HRID 255533 reaction equation
[NH2:1][C:2]1[C:3]([CH3:15])=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH3:13])=[CH:9][C:8]([F:14])=[CH:7][CH:6]=2.[CH:16](O)=O>>[CH3:13][N:12]1[C:11]2[C:10]3[CH:9]=[C:8]([F:14])[CH:7]=[CH:6][C:5]=3[N:4]=[C:3]([CH3:15])[C:2]=2[N:1]=[CH:16]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 13958357HCID 13958357, compound

Product 1

HCID 13958443HCID 13958443, compound

Procedure

Using the method of Example 137, 3-amino-6-fluoro-2-methyl-4-methylaminoquinoline (from example 44) was reacted with formic acid to provide 1,4-dimethyl-8-fluoro-1H-imidazo[4,5-c]quinoline, m.p. 184°-186° C. Analysis: Calculated for C12H10FN3 : %C, 67.0; %H, 4.7; %N, 19.5; Found: %C, 66.6; %H, 4.4; %N, 19.7.

Sources & evidence

ORD record
ord-c2d97a27baf5463f8ee33dc0d8b7de4b
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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