Trifluoroacetic acid → 2-trifluoromethyl-1H-imidazo[4,5-c]quinoline

HRID 255538Notes

Reaction equation

HRID 255538 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH2:12])=[CH:9][CH:8]=[CH:7][CH:6]=2.[F:13][C:14]([F:19])([F:18])[C:15](O)=O>>[F:13][C:14]([F:19])([F:18])[C:15]1[NH:12][C:11]2[C:10]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:4]=[CH:3][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15142893,4-Diaminoquinoline

Product 1

HCID 1785062732-trifluoromethyl-1H-imidazo[4,5-c]quinoline

Procedure

Using the method of Example 144, 3,4-diaminoquinoline (from Example 39) was reacted with trifluoroacetic acid to provide 2-trifluoromethyl-1H-imidazo[4,5-c]quinoline, m.p. 252°-254° C. Analysis: Calculated for C11H6F3N3 : %C, 55.7; %H, 2.5; %N, 17.7; Found: %C, 55.3; %H, 2.3; %N, 18.2.

Sources & evidence

ORD record
ord-408905d33a684dd38352d9d5d380ff5d
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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