Methylamine → HCID 13958458, compound

HRID 255543Notes

Reaction equation

HRID 255543 reaction equation
[CH3:1][NH2:2].Cl[C:4]1[C:13]2[N:14]=[CH:15][N:16]([CH3:17])[C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1>>[CH3:1][NH:2][C:4]1[C:13]2[N:14]=[CH:15][N:16]([CH3:17])[C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 13958418HCID 13958418, compound

Product 1

HCID 13958458HCID 13958458, compound

Conditions

Temperature
112 °C

Procedure

A mixture of 40% aqueous methylamine (25 ml) and 5.0 g (0.023 mole) of 4-chloro-1-methyl-1H-imidazo[4,5-c]quinoline (from Example 114) was placed in a metal pressure reactor and heated at 112° C. for about 16 hours. After cooling, the solid was separated by filtration, washed with water, dried and recrystallized from ethanol to provide N,1-dimethyl-1H-imidazo[4,5-c]quinolin-4-amine, m.p. 216°-218° C. Analysis: Calculated for C12H12N4 : %C, 67.9; %H, 5.7; %N, 26.4; Found: %C, 67.9; %H, 5.6; %N, 26.4.

Workup

  1. customwas placed in a metal pressure reactor
  2. temperatureAfter cooling
  3. customthe solid was separated by filtration
  4. washwashed with water
  5. customdried
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-e00b9140cbd34e27a71e4dee98d9384d
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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