Sodium Methoxide → HCID 13958463, compound

HRID 255546Notes

Reaction equation

HRID 255546 reaction equation
Cl[C:2]1[C:11]2[N:12]=[CH:13][N:14]([CH2:15][CH:16]([OH:19])[CH2:17][OH:18])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:20][O-:21].[Na+]>>[OH:19][CH:16]([CH2:17][OH:18])[CH2:15][N:14]1[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=[C:2]([O:21][CH3:20])[C:11]=2[N:12]=[CH:13]1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 13958428HCID 13958428, compound

Product 1

HCID 13958463HCID 13958463, compound

Procedure

Using the method of Example 157, 4-chloro-1-(2,3-dihydroxypropyl)-1H-imidazo[4,5-c]quinoline (from Example 124, Part D) was reacted with sodium methoxide to provide 1-(2,3-dihydroxypropyl)-4-methoxy-1H-imidazo[4,5-c]quinoline, m.p. 214°-216° C. after recrystallization from isopropanol. Analysis: Calculated for C14H15N3O3 : %C, 61.5; %H, 5.5; N, 15.4; Found: %C, 61.3; %H, 5.5; %N, 15.4.

Sources & evidence

ORD record
ord-af45110263d847a981a840f590c19e5c
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Reaction notes

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