反应详情

A mixture consisting of 11.7 g of 3-aminobenzisothiazole, 126 ml of acetanhydride and 0.2 g of sodium acetate is stirred for 48 hours at 100°-110? C. After concentration by evaporation and then chromatography (silica gel; eluant: hexane/diethyl ether 2:1), the product is recrystallised from hexane/diethyl ether to thus obtain the compound No. 1 of the formula ##STR10## having a melting point of 65°-67° C.

1. concentrationAfter concentration
2. customby evaporation
3. customchromatography (silica gel; eluant: hexane/diethyl ether 2:1), the product is recrystallised from hexane/diethyl ether
4. customto thus obtain the compound No