反应详情

With 1 g of 6-(4-dimethylaminophenyl)-1-(4-hydroxyphenyl)-4-oxo-1,4-dihydronicotinic acid was mixed 10 ml of acetic anhydride and the resulting mixture was subjected to reaction at 130° C. for 2 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and introduced into 150 ml of water. After stirring the mixture for 1 hour, 150 ml of ethyl acetate was added to the mixture, and the organic layer was separated, washed with 100 ml of water and then with 50 ml of a saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and to the residue was added 20 ml of diethyl ether, and the resulting mixture was filtered to obtain 0.75 g of 1-(4-acetyloxyphenyl)-6-(4-dimethylaminophenyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 128°-131° C.

1. customthe resulting mixture was subjected to reaction at 130° C. for 2 hours
2. customAfter completion of the reaction
3. customthe organic layer was separated
4. washwashed with 100 ml of water
5. dry with materialwith 50 ml of a saturated aqueous solution of sodium chloride, and dried with anhydrous magnesium sulfate
6. customThe solvent was removed by distillation under reduced pressure
7. additionto the residue was added 20 ml of diethyl ether
8. filtrationthe resulting mixture was filtered