Hydrochloric Acid → HCID 54158343, compound

HRID 255676Notes

Reaction equation

HRID 255676 reaction equation
C([O:3][C:4]([CH:6]=[CH:7][C:8]1[N:9]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=2[CH3:25])[CH:10]=[C:11]([C:15](=[O:17])[CH:16]=1)[C:12]([OH:14])=[O:13])=[O:5])C.Cl>C(OCC)C>[C:4]([CH:6]=[CH:7][C:8]1[N:9]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=2[CH3:25])[CH:10]=[C:11]([C:15](=[O:17])[CH:16]=1)[C:12]([OH:14])=[O:13])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70435233HCID 70435233, compound

Product 1

HCID 54158343HCID 54158343, compoundYield 96.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 0.09 g of 6-(2-ethoxycarbonylethenyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinic acid was added 3 ml of 6N hydrochloric acid, and they were reacted at 100° C. for 1.5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and to the crystals thus formed were added 3 ml of diethyl ether, and the resulting mixture was filtered to obtain 0.08 g of 6-(2-carboxyethenyl)-1-(4-hydroxy-2-methylphenyl)-4-oxo-1,4-dihydronicotinic acid having a melting point of 280° C. or more.

Workup

  1. customwere reacted at 100° C. for 1.5 hours
  2. customAfter completion of the reaction
  3. customthe solvent was removed by distillation under reduced pressure
  4. customto the crystals thus formed
  5. filtrationthe resulting mixture was filtered

Sources & evidence

ORD record
ord-b6a60045473d45cb9fa453267c19ae2a
Source dataset
uspto-grants-1987_10
Patent number
US04698352

Reaction notes

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