反应详情

A mixture of 4-hydroxy-3-nitrobenzaldehyde (43.5 g), acetylacetone (26 g), acetic acid (3.12 g) and piperidine (1.03 ml) in benzene (26 ml) was refluxed for 1 hours under azeotropic dehydration. To the reaction mixture was added 100 ml of diethyl ether. The mixture was washed with water (100 ml) and a saturated aqueous solution of sodium chloride (50 ml), dried over magnesium sulfate and evaporated in vacuo to afford 2-(4-hydroxy-3-nitrobenzylidene)acetylacetone (55.0 g).

1. temperaturewas refluxed for 1 hours under azeotropic dehydration
2. washThe mixture was washed with water (100 ml)
3. dry with materiala saturated aqueous solution of sodium chloride (50 ml), dried over magnesium sulfate
4. customevaporated in vacuo