反应详情

To a solution of ethyl 4-nitrobenzoylacetate (11.9 g) in benzene (100 ml) was dropwise added N,N-dimethylformamide dimethylacetal (9.5 g) dissolved in benzene (50 ml) during a period of 0.5 hour, under stirring at room temperature. The mixture was refluxed for 4 hours. The reaction mixture was evaporated under reduced pressure. The resulting oil was recrystallized from ether-hexane to give 12.5 g of ethyl 2-(4-nitrobenzoyl)-3-dimethylaminopropenoate.

1. temperatureThe mixture was refluxed for 4 hours
2. customThe reaction mixture was evaporated under reduced pressure
3. customThe resulting oil was recrystallized from ether-hexane