Chloroform → HCID 20183313, compound

HRID 255708Notes

Reaction equation

HRID 255708 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)N[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9].[S].[CH:28](Cl)(Cl)Cl>>[CH3:1][C:2]1[N:3]=[C:4]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:28]=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 5362487SulfurHCID 178418551HCID 178418551, compound

Product 1

HCID 20183313HCID 20183313, compound

Conditions

Temperature
150 °C

Procedure

A mixture of methyl 1,6-dihydro-4-methyl-6-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (0.5 g) and sulfur powder (0.046 g) was heated at 150° C. for 1 hour. After cooling, the mixture was dissolved in chloroform and filtered. The filtrate was evaporated under reduced pressure to give a crystal of methyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyridinecarboxylate (0.2 g).

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. customThe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-927a60651f6e47d38a89f16b60d4c9bf
Source dataset
uspto-grants-1987_10
Patent number
US04698340

Reaction notes

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