Fumaric Acid → N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide fumarate

HRID 255725Notes

Reaction equation

HRID 255725 reaction equation
[CH3:1][N:2]([CH3:30])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=2)=[N:10][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:12][C:13]=1[CH3:14])=[O:7].[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>C(O)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH3:30][N:2]([CH3:1])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-:29])=[O:28])[CH:22]=2)=[N:10][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:12][C:13]=1[CH3:14])=[O:7]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 10319094N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide

Product 1

HCID 20183348N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide fumarate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To the solution of N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide (4 g) in ethyl alcohol (10 ml), the solution of fumaric acid (1.15 g) in hot ethyl alcohol (10 ml) was added. The precipitate was filtered off to afford N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide fumarate.

Workup

  1. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-4212d1f4f87f446797b850813e51097c
Source dataset
uspto-grants-1987_10
Patent number
US04698340

Reaction notes

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