反应详情

Conc. hydrochloric acid (0.5 ml.) was added to a solution of 7-[2-(2-formamidothiazol-4-yl)-2-(3-tert-butoxycarbonylaminopropoxyimino)acetamido]-3-(1-allyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.1 g.) in methanol (20 ml.) and stirred at room temperature for an hour. After evaporating the solvent in vacuo, methanol was added to the residue and evaporated again. The residue was dried over phosphorus pentoxide in vacuo to give 7-[2-(2-aminothiazol-4-yl)-2-(3-aminopropoxyimino)acetamido]-3-(1-allyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid dihydrochloride (syn isomer, 0.89 g.).

1. customAfter evaporating the solvent in vacuo, methanol
2. additionwas added to the residue
3. customevaporated again
4. dry with materialThe residue was dried over phosphorus pentoxide in vacuo