Trifluoroacetic acid → HCID 13923713, compound

HRID 255834Notes

Reaction equation

HRID 255834 reaction equation
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH:16]C(C)(C)C)(=[O:15])=[O:14])(=[O:3])[CH3:2].FC(F)(F)C(O)=O>>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH2:16])(=[O:14])=[O:15])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15616509HCID 15616509, compound

Product 1

HCID 13923713HCID 13923713, compoundYield 81.9%

Procedure

The product from Example 5 (13.8 g) was added in portions to 75 ml of trifluoroacetic acid at room temperature and the resulting solution was stirred for 21 hours. Removal of the trifluoroacetic acid in vacuo gave a light orange oil which crystallized upon addition of diethyl ether. Filtration and air drying yielded 9.18 g of pure 2-[2-(acetyloxy)ethyl]benzenesulfonamide as a white powder, m.p. 116°-117.5° C.

Workup

  1. customRemoval of the trifluoroacetic acid in vacuo
  2. customgave a light orange oil which
  3. customcrystallized upon addition of diethyl ether
  4. filtrationFiltration and air
  5. customdrying

Sources & evidence

ORD record
ord-c9ba7d3c50f14375a8abcb9e0e0cec5e
Source dataset
uspto-grants-1987_10
Patent number
US04699650

Reaction notes

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