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HRID25586

反应详情

EQUATION

反应方程式

HRID 25586 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](C=C(Br)Br)CC1
HCID178486027

未命名化合物

PRODUCTS

生成物

1
结构：CN[C@H]1CC[C@H](C=C(Br)Br)CC1
HCID178484791

未命名化合物

收率 100.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 975 mg (3.28 mmol) of trans-[4-(2,2-Dibromo-vinyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester in 20 ml CH2Cl2 was treated at 0° C. with 10 ml TFA (for 20 min). After 2 h at RT, the reaction was evaporated, treated with aqueous saturated NaHCO3(+Na2CO3)/Et2O (3×), dried over Na2SO4 and evaporated to yield 981 mg (87%) of trans-[4-(2,2-Dibromo-vinyl)-cyclohexyl]-methyl-amine, MS: 295 (M, 2Br).

WORKUP

后处理

  1. customthe reaction was evaporated
  2. additiontreated with aqueous saturated NaHCO3(+Na2CO3)/Et2O (3×)
  3. dry with materialdried over Na2SO4
  4. customevaporated