Fluoride Ion → HCID 13959042, compound

HRID 255867Notes

Reaction equation

HRID 255867 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[N:10][CH:9]=[C:8]2[C:13]([O:15][CH3:16])=[O:14].[F-:17]>C1C=CC=CC=1>[F:17][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[N:10][CH:9]=[C:8]2[C:13]([O:15][CH3:16])=[O:14]

Participants

4

Reactant 2

HCID 28179Fluoride IonHCID 13959041HCID 13959041, compound

Product 1

HCID 13959042HCID 13959042, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 0.35 g of 58B, 3.0 g of Amberlyst A26 fluoride resin and 5 ml of benzene was stirred vigorously at mild reflux in a nitrogen atmosphere overnight. The resulting mixture was filtered, and the filtrate was stripped of solvent. The residue was chromatographed over silica gel, using a 1:99 v:v mixture of ethyl acetate and methylene chloride as eluent, to give 58, as a yellow solid, m.p.: 104°-105° C.

Workup

  1. temperatureat mild reflux in a nitrogen atmosphere overnight
  2. filtrationThe resulting mixture was filtered
  3. customThe residue was chromatographed over silica gel
  4. additionv mixture of ethyl acetate and methylene chloride as eluent

Sources & evidence

ORD record
ord-886f17c9dfef4bcc9c547fe867cb3d28
Source dataset
uspto-grants-1987_10
Patent number
US04699651

Reaction notes

Loading…