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HRID25587

反应详情

EQUATION

反应方程式

HRID 25587 的结构方程式

REACTANTS

反应物

1
结构：CCN(CC#C[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(Cl)cc2)CC1)CCO
HCID178464020

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CCO)CCC[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(Cl)cc2)CC1
HCID178464460

未命名化合物

收率 32.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pt]
催化剂HCID23939

Platinum

Pt

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A suspension of 65 mg (0.165 mmol) of trans-(4-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-prop-1-ynyl}-cyclohexyl)-methyl-carbamic acid 4-chloro-phenyl ester in 5 ml MeOH and 7 mg Pt/C 10% was hydrogenated (1 atm) for 16 h. The reaction was filtered (Celite) and evaporated. Flash column chromatography on silica gel with CH2Cl2/MeOH (9:1) gave 21 mg (32%) of trans-(4-{3-[Ethyl-(2-hydroxy-ethyl)-amino]-propyl}-cyclohexyl)-methyl-carbamic acid 4-chloro-phenyl ester, MS: 397 (MH+, 1Cl).

WORKUP

后处理

  1. customfor 16 h
  2. filtrationThe reaction was filtered (Celite)
  3. customevaporated