反应详情

To a refluxing suspension of 3-(4-nitrophenyl)-pyrazole (18 g) and Raney nickel (3.3 g) in methanol (190 ml) was added dropwise a solution of 85% hydrazine hydrate (22 g) in methanol (50 ml). The solution was refluxed for 30 minutes more, filtered and evaporated to dryness. The oily residue, after crystallization from water, furnished 14.5 g of 3-(4-aminophenyl)-pyrazole; M.p. 104° C. 3-(3-Aminophenyl)-pyrazole, M.p. 144°-145° C., was prepared in a similar manner starting from 3-nitroacetophenone.

1. temperatureThe solution was refluxed for 30 minutes more
2. filtrationfiltered
3. customevaporated to dryness
4. customThe oily residue, after crystallization from water