Acrylamide → HCID 13604755, compound

HRID 255904Notes

Reaction equation

HRID 255904 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][C:13](=O)[CH3:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O1CCOCC1.[C:22]([NH2:26])(=[O:25])[CH:23]=[CH2:24].CC(C)([O-])C.[K+]>O>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH2:24][CH2:23][C:22](=[O:25])[NH:26][C:13]=3[CH3:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 4

HCID 6579AcrylamideHCID 312751,4-DioxaneHCID 133942271-[4-(1-Imidazolyl)-phenyl]-2-propanoneHCID 23665647Potassium tert-butoxide

Product 1

HCID 13604755HCID 13604755, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3 g 1-[4-(1-imidazolyl)-phenyl]-2-propanone (EPA 102 227, example 4), 30 ml 1,4-dioxane, 1,2 g acrylic acid amide and 1.73 g potassium tert-butoxide is stirred for 40 minutes at room temperature and subsequently for 2 hours at 100° C. After cooling it, water is added, the precipitated solid is sucked off, washed with water, dried and purified by column chromatography (silica gel/dichloromethan/methanol).

Workup

  1. additionis added
  2. washwashed with water
  3. customdried
  4. custompurified by column chromatography (silica gel/dichloromethan/methanol)

Sources & evidence

ORD record
ord-0e01a24cfe92438b80494a559a0364d9
Source dataset
uspto-grants-1987_10
Patent number
US04699914

Reaction notes

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