反应详情

温度

100 °C

A mixture of 3 g 1-[4-(1-imidazolyl)-phenyl]-2-propanone (EPA 102 227, example 4), 30 ml 1,4-dioxane, 1,2 g acrylic acid amide and 1.73 g potassium tert-butoxide is stirred for 40 minutes at room temperature and subsequently for 2 hours at 100° C. After cooling it, water is added, the precipitated solid is sucked off, washed with water, dried and purified by column chromatography (silica gel/dichloromethan/methanol).

1. additionis added
2. washwashed with water
3. customdried
4. custompurified by column chromatography (silica gel/dichloromethan/methanol)