Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylamide | HCID 6579 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-[4-(1-Imidazolyl)-phenyl]-2-propanone | HCID 13394227 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13604755 | HCID 13604755 | — |
Reaction Steps
A mixture of 3 g 1-[4-(1-imidazolyl)-phenyl]-2-propanone (EPA 102 227, example 4), 30 ml 1,4-dioxane, 1,2 g acrylic acid amide and 1.73 g potassium tert-butoxide is stirred for 40 minutes at room temperature and subsequently for 2 hours at 100° C. After cooling it, water is added, the precipitated solid is sucked off, washed with water, dried and purified by column chromatography (silica gel/dichloromethan/methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04699914 |
|---|
| Source dataset | uspto-grants-1987_10 |
|---|
| ORD ID | ord-0e01a24cfe92438b80494a559a0364d9 |
|---|
| Source note | uspto-grants-1987_10 |
|---|
