Beta-Alanine → HCID 56616504, compound

HRID 255906Notes

Reaction equation

HRID 255906 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:11]=O)[S:9][CH:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[N+:13]([CH2:16][CH3:17])([O-:15])=[O:14].NCCC(O)=O>C(O)CCC>[N+:13]([C:16]([CH3:17])=[CH:11][C:8]1[S:9][CH:10]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH:7]=1)([O-:15])=[O:14]

Participants

5

Reactant 3

HCID 239Beta-AlanineHCID 6587NitroethaneHCID 133187124-(1H-Imidazol-1-yl)thiophene-2-carbaldehyde

Product 1

HCID 56616504HCID 56616504, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 94 g 4-(1-imidazolyl)-thiophene-2-aldehyde (EPA 112 987), 47.7 g nitroethane, 4.9 g β-alanine and 327 ml n-butanol is stirred for 9 hours at reflux temperature. Subsequently, it is evaporated and the residue is purified by column chromatography (silica gel//dichloromethane/methanol).

Workup

  1. temperatureat reflux temperature
  2. customSubsequently, it is evaporated
  3. customthe residue is purified by column chromatography (silica gel//dichloromethane/methanol)

Sources & evidence

ORD record
ord-faaad6aeea7b43efb81e26b571a0b098
Source dataset
uspto-grants-1987_10
Patent number
US04699914

Reaction notes

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