HCID 13958746, compound → HCID 13958747, compound

HRID 255916Notes

Reaction equation

HRID 255916 reaction equation
[F:1][CH:2](F)[C:3](C(OCC)=O)([CH3:11])[C:4]([O:6][C:7](C)(C)[CH3:8])=[O:5]>FC(F)(F)C(O)=O>[CH3:11]/[C:3](=[CH:2]\[F:1])/[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

3

Reactant 1

HCID 13958746HCID 13958746, compound

Product 1

HCID 13958747HCID 13958747, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl 2-difluoromethyl-2-carbethoxypropionate (392 g) (prepared in Step B) in trifluoroacetic acid (TFA) (400 ml) is stirred at room temperature for several hours, then the excess TFA is removed by evaporation at reduced pressure. The residue is treated with carbon tetrachloride and re-evaporated.

Workup

  1. customthe excess TFA is removed by evaporation at reduced pressure
  2. additionThe residue is treated with carbon tetrachloride
  3. customre-evaporated

Sources & evidence

ORD record
ord-f8b7820c7bfd4a4f978e7a932890c91c
Source dataset
uspto-grants-1987_10
Patent number
US04699928

Reaction notes

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