Trifluoroacetic acid → HCID 178484796, compound

HRID 25595Notes

Reaction equation

HRID 25595 reaction equation
C(O[C:6]([N:8](C)[C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH2:11][CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:6][NH:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178486032HCID 178486032, compound

Product 1

HCID 178484796HCID 178484796, compoundYield 166.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

200 mg (0.53 mmol) of trans-Methansulfonic acid 5[-4-(tert-butoxy carbonyl-methyl-amino)-cyclohexyl)-pentyl ester, dissolved in 2 ml of CH2Cl2, was treated with 2 ml of TFA. After stirring for 20 min at RT, the solution was concentrated in vacuo to yield 245 mg of pure trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentylester.trifluoroacetic acid salt, MS: 278 (MH+).

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-5ac50a9b73ce4cf084179954503a48e5
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

Loading…