反应详情

14.35 g of 3-dimethylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile are refluxed with 3.2 g of cyclopropylamine and 60 ml of toluene. When the evolution of gas is finished after about 30 minutes, the toluene is removed by distillation in vacuo, and the residue is recrystallized from ethanol/light petroleum. 13.8 g of 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile of melting point 94°-95° C. are obtained.

1. customthe toluene is removed by distillation in vacuo
2. customthe residue is recrystallized from ethanol/light petroleum