HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 3-Cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3-Dimethylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile | HCID 53996767 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile | HCID 67944919 | 92.3% |
Reaction Steps
14.35 g of 3-dimethylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile are refluxed with 3.2 g of cyclopropylamine and 60 ml of toluene. When the evolution of gas is finished after about 30 minutes, the toluene is removed by distillation in vacuo, and the residue is recrystallized from ethanol/light petroleum. 13.8 g of 3-cyclopropylamino-2-(2,4-dichloro-5-fluorobenzoyl)acrylonitrile of melting point 94°-95° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699992 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-d0c2697f1f424dbd80cd21248921cf08 |
| Source note | uspto-grants-1987_10 |