Methylhydrazine → t-butyl alpha-[6(R)-amino-5-oxo-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetate

Participants

Reaction Steps

1.18 g of t-butyl α-[5-oxo-6(R)-phthalimido-3(S)-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetate [prepared as described in step (f) above] was subjected to de-phthaloylization with methylhydrazine in the manner described in Example 1(g), to give 0.77 g of the title compound as an amorphous solid.

Provenance & Evidence