HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → alpha-{6-[1-Butoxycarbonyl-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyl alpha-{6-[1-butoxycarbonyl-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetate | HCID 20164825 | — |
| Product | alpha-{6-[1-Butoxycarbonyl-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetic acid | HCID 20164845 | — |
Reaction Steps
0.12 g of isomer B of t-butyl α-[6-(1-butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl]acetate (prepared as described in Example 19 above) was subjected to de-t-butylation with trifluoroacetic acid in the manner described in Example 3, to give 78 mg of the title compound as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-4e98b536881343178325672347eaea36 |
| Source note | uspto-grants-1987_10 |