Trifluoroacetic acid → alpha-{6-[1-Butoxycarbonyl-3-phenylpropylamino]-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl}acetic acid
Reaction equation
[CH2:1]([O:5][C:6]([CH:8]([NH:17][CH:18]1[CH2:24][S:23][CH:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:21][N:20]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[C:19]1=[O:39])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4].FC(F)(F)C(O)=O>>[CH2:1]([O:5][C:6]([CH:8]([NH:17][CH:18]1[CH2:24][S:23][CH:22]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:21][N:20]([CH2:31][C:32]([OH:34])=[O:33])[C:19]1=[O:39])[CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:7])[CH2:2][CH2:3][CH3:4]Participants
3
Procedure
0.12 g of isomer B of t-butyl α-[6-(1-butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl]acetate (prepared as described in Example 19 above) was subjected to de-t-butylation with trifluoroacetic acid in the manner described in Example 3, to give 78 mg of the title compound as an amorphous solid.
Sources & evidence
- ORD record
- ord-4e98b536881343178325672347eaea36
- Source dataset
- uspto-grants-1987_10
- Patent number
- US04699905
Reaction notes
Loading…