Hydrochloric Acid → HCID 13854115, compound

HRID 256055Notes

Reaction equation

HRID 256055 reaction equation
C([O:3][C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>>[C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13854097alpha-[6-(1-Ethoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid

Product 1

HCID 13854115HCID 13854115, compound

Procedure

150 mg of α-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid (prepared as described in Example 43) were mixed with 2 ml of a 1N aqueous solution of sodium hydroxide, and the mixture was stirred for 16 hours. The reaction mixture was then adjusted to a pH value of 2.0 with 1N hydrochloric acid and the resulting solid, which was the title compound, was collected by filtration and washed with small amount of water and diisopropyl ether, to yield 120 mg.

Sources & evidence

ORD record
ord-a7e90e7de9a74a92938a91b7b6874c18
Source dataset
uspto-grants-1987_10
Patent number
US04699905

Reaction notes

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