tert-Butyl bromoacetate → HCID 13854079, compound

HRID 256061Notes

Reaction equation

HRID 256061 reaction equation
[O:1]=[C:2]1[CH:8]([N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])[CH2:7][S:6][CH:5]([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[CH2:4][NH:3]1.Br[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28]>>[O:1]=[C:2]1[CH:8]([N:9]2[C:13](=[O:14])[C:12]3=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]3[C:10]2=[O:19])[CH2:7][S:6][CH:5]([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[CH2:4][N:3]1[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 138540775-Oxo-6-phthalimido-2-(2-thienyl)perhydro-1,4-thiazepine

Product 1

HCID 13854079HCID 13854079, compound

Procedure

Following the procedure described in Example 42(f), 1.6 g of 5-oxo-6-phthalimido-2-(2-thienyl)perhydro-1,4-thiazepine [prepared as described in step (e) above] was treated with t-butyl bromoacetate to give 1.15 g of the title compound as crystals, melting at 183°-184° C.

Sources & evidence

ORD record
ord-82b224ddffc643afb22c01fc9463f645
Source dataset
uspto-grants-1987_10
Patent number
US04699905

Reaction notes

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