Trifluoroacetic acid → alpha-[6-(1-Butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid
Reaction equation
[CH2:1]([O:5][C:6]([CH:8]([NH:17][CH:18]1[CH2:24][S:23][CH:22]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[CH2:21][N:20]([CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[C:19]1=[O:38])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4].FC(F)(F)C(O)=O>>[CH2:1]([O:5][C:6]([CH:8]([NH:17][CH:18]1[CH2:24][S:23][CH:22]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[CH2:21][N:20]([CH2:30][C:31]([OH:33])=[O:32])[C:19]1=[O:38])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4]Participants
3
Procedure
Following the procedure described in Example 43, 120 mg of isomer B of t-butyl α-[6-(1-butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetate (prepared as described in Example 52) were de-t-butylated using trifluoroacetic acid, to afford 75 mg of the title compound as a powder.
Sources & evidence
- ORD record
- ord-a8a71885a97b48018654ff00c5e9b3bd
- Source dataset
- uspto-grants-1987_10
- Patent number
- US04699905
Reaction notes
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