tert-Butyl bromoacetate → t-Butyl alpha-[2-(2-furyl)-5-oxo-6-phthalimidoperhydro-1,4-thiazepin-4-yl]acetat

HRID 256070Notes

Reaction equation

HRID 256070 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:12][NH:11][C:10](=[O:13])[CH:9]([N:14]2[C:18](=[O:19])[C:17]3=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]3[C:15]2=[O:24])[CH2:8][S:7]1.Br[CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28]>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:12][N:11]([CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:10](=[O:13])[CH:9]([N:14]2[C:18](=[O:19])[C:17]3=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]3[C:15]2=[O:24])[CH2:8][S:7]1

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 138540832-(2-Furyl)-5-oxo-6-phthalimidoperhydro-1,4-thiazepine

Product 1

HCID 13854084t-Butyl alpha-[2-(2-furyl)-5-oxo-6-phthalimidoperhydro-1,4-thiazepin-4-yl]acetat

Procedure

Following the procedure described in Example 42(f), 1.15 g of 2-(2-furyl)-5-oxo-6-phthalimidoperhydro-1,4-thiazepine [prepared as described in step (d) above] was treated with t-butyl bromoacetate, to give 0.86 g of the title compound as crystals, melting at 158°-161° C.

Sources & evidence

ORD record
ord-2cb75d71af9c4868b701e88d62fb3407
Source dataset
uspto-grants-1987_10
Patent number
US04699905

Reaction notes

Loading…