Sodium Hydroxide → HCID 13854113, compound

HRID 256084Notes

Reaction equation

C([O:3][C:4]([C@@H:6]([NH:15][C@H:16]1[CH2:22][S:21][CH:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+]>>[C:4]([C@@H:6]([NH:15][C@H:16]1[CH2:22][S:21][CH:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)[CH2:19][N:18]([CH2:28][C:29]([OH:31])=[O:30])[C:17]1=[O:32])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 13854104alpha-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid

Product 1

HCID 13854113HCID 13854113, compoundYield 86.3%

Procedure

The procedure described in Example 44 was repeated, except that 80 mg of α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 64) were used as the starting material. After hydrolysis of the starting material with sodium hydroxide, 65 mg of the title compound were obtained as a powder.

Sources & evidence

ORD record: ord-467f9ff619064c4ca280a80ad94578f6
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04699905

Reaction notes

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